HHMI UCB LBL

Research

Structural Basis Of Microtubule Dynamic Instabilityimage
Microtubule-Kinetochore Interfaceimage
Septin Structure and Assemblyimage
Cytoskeletal Self-Assembly
in Cell Division
Transcription Initiationimage
Transscriptional Repressionimage
Gene Silencingimage
CRISPR-mediated prokaryotic immunityimage
Regulation of
Gene Expression
Proteasome-mediated proteolysisimage
RNA Processing by the Exasomeimage
Eukaryotic DNA Replication: Origin Recognition Complex (ORC)image
Past Collaberative
Projects

News

Recent publications

Greber et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/28902838\ > The cryo-electron microscopy structure of human transcription factor IIH. </a> Nature Epub Sep 13 Wright AV, Liu JJ et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/28729350\ > Structures of the CRISPR genome integration complex. </a> Science Epub 2017 Jul 20 Kellogg et al. <a href=http://www.sciencedirect.com/science/article/pii/S0022283617300153\> Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures</a><i> Journal of Molecular Biology</i>, 2017 Mar 10 He et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/27193682\> Near-atomic resolution visualization of human transcription promoter opening</a><i> Nature</i>, 2016 May 11 Louder et al. <a href=http://www.ncbi.nlm.nih.gov/pubmed/27007846> Structure of promoter-bound TFIID and model of human pre-initiation complex assembly</a><i> Nature</i>, 2016 Mar 23;531(7596):604-9 Jiang and Taylor et al. <a href=http://www.ncbi.nlm.nih.gov/pubmed/26841432> Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.</a> <i>Science</i>, Jan 2016 Nogales and Zhang<a href=http://www.sciencedirect.com/science/article/pii/S0959440X16000038> Visualizing microtubule structural transitions and interactions with associated proteins</a> <i>COSB</i>, April 2016; <b>37</b>, 90-96 Zhang et al. <a href=http://www.sciencedirect.com/science/article/pii/S0092867415008491> Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins</a><i> Cell 2015 Aug 13;162(4):849-59

Harvey Lecture by Eva Nogales