Research

Electron Microscopy of Macromolecular Assemblies

The Nogales’s lab is dedicated to gaining mechanistic insight into two important areas of eukaryotic biology: central dogma machinery in the control of gene expression, and cytoskeleton interactions and dynamics in cell division. The unifying principle in our work is the study of macromolecular assemblies as whole units of molecular function by direct visualization of their architecture, functional states, and regulatory interactions. To gain a molecular understanding of their systems of interest, our lab uses state-of-the-art cryo-electron microscopy (cryo-EM) and image analysis, as well as biochemical and biophysical assays.

Research

  • All
  • Microtubules
  • Gene Expression
  • Past Collaborations

Gene Silencing/PRC2

Epigenetics

Phycobilisome

Past Collaborations

CRISPR

Past Collaborations

TFIIH

Transcription

TFIID

Transcription

SAGA Complex

Transcription