Gene Silencing/PRC2
Polycomb Repressive Complex 2 (PRC2) trimethylates histone H3K27 to silence specific genes. It’s role is especially critical during development and for the maintenance of cell identity. In spite of its biological importance, when we began working on PRC2 little was known about the complex’s architecture and subunit organization. Prior to the resolution revolution, we reconstituted a [...]