HHMI UCB LBL

Animations

The following animations give structural insights of several macrmolecular complexes

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

Near-atomic model of microtubule-tau interactions

Structures of human PRC2 with its cofactors AEBP2 and JARID2

Cryo-EM structure of subtrate-bound human telomerase holoenzyme

Structural insight into TPX2-simulated microtubule assembly

News

Recent publications

Patel et al. <a href=http://science.sciencemag.org/content/early/2018/11/14/science.aau8872> Structure of human TFIID and mechanism of TBP loading onto promoter DNA </a> Science 2018 Nov 15 Kellogg et al. <a href=http://science.sciencemag.org/content/early/2018/05/09/science.aat1780?rss=1> Near-atomic model of microtubule-tau interactions </a> Science 2018 May 10 Nguyen et al. <a href= https://www.nature.com/articles/s41586-018-0062-x> Cryo-EM structure of substrate-bound human telomerase holoenzyme. </a> Nature 2018 Apr 25 Poepsel et al. <a href=https://www.nature.com/articles/s41594-018-0023-y > Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes. </a> Nature Structural and Molecular Biology 2018 Jan 29 Kasinath et al. <a href=http://science.sciencemag.org/content/early/2018/01/17/science.aar5700 > Structures of human PRC2 with its cofactors AEBP2 and JARID2. </a> Science 2018 Jan 18 Haloupek et al. <a href=http://science.sciencemag.org/content/358/6365/888 > The structural basis of flagellin detection by NAIP5: a strategy to limit pathogen immune evasion. </a> Science 2017 Nov 17 Zhang et al. <a href=https://elifesciences.org/articles/30959 > Structural Insight into TPX2-Stimulated Microtubule Assembly.</a> Elife 2017 Nov 9 Greber et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/28902838\ > The cryo-electron microscopy structure of human transcription factor IIH. </a><i> Nature </i>, 2017 Sep 21;549(7672):414-417 Wright AV, Liu JJ et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/28729350\ > Structures of the CRISPR genome integration complex. </a> Science 2017 Sep 15 Kellogg et al. <a href=http://www.sciencedirect.com/science/article/pii/S0022283617300153\> Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures</a><i> Journal of Molecular Biology</i>, 2017 Mar 10 He et al. <a href=https://www.ncbi.nlm.nih.gov/pubmed/27193682\> Near-atomic resolution visualization of human transcription promoter opening</a><i> Nature</i>, 2016 May 11 Louder et al. <a href=http://www.ncbi.nlm.nih.gov/pubmed/27007846> Structure of promoter-bound TFIID and model of human pre-initiation complex assembly</a><i> Nature</i>, 2016 Mar 23;531(7596):604-9 Jiang and Taylor et al. <a href=http://www.ncbi.nlm.nih.gov/pubmed/26841432> Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.</a> <i>Science</i>, Jan 2016 Nogales and Zhang<a href=http://www.sciencedirect.com/science/article/pii/S0959440X16000038> Visualizing microtubule structural transitions and interactions with associated proteins</a> <i>COSB</i>, April 2016; <b>37</b>, 90-96 Zhang et al. <a href=http://www.sciencedirect.com/science/article/pii/S0092867415008491> Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins</a><i> Cell 2015 Aug 13;162(4):849-59

Rosalind Franklin Lecture by Eva Nogales

Eva Nogales is the 2019 recipient of the Grimwade Medal

Eva Nogales has been elected Fellow of ASCB

Harvey Lecture by Eva Nogales